People

Failure is not final

Lena Wiegmann

PhD Student University of Zürich
Institute of Physiology
Winterthurerstr. 190, Y23 J 78
8057 Zürich
+41 (0) 44 635 50 56lena.wiegmann@uzh.ch

Short Biography

Lena joined the Interface Group in October 2014 as a PhD student after graduating from ETH Zurich with a master’s degree in mechanical engineering. During her studies, she received a scholarship of the German National Academic Foundation (“Studienstiftung des Deutschen Volkes”) and was accepted to the Femtec program, which supports talented female engineering students. She conducted research projects at Oxford and Harvard University, which were focused on biomedical engineering and biomechanics. Her master thesis with Prof. Ralph Müller (ETHZ) was about multiscale modeling of bone failure prediction, combining finite element analyses at different scales. In general, her interest lies in the application of engineering solutions to solve current challenges in medicine.

Research Goals

The goal of her research at the Interface group is the development of a novel model for blood damage in ventricular assist devices, which are artificial hearts that can support or substitute the patient’s heart function. This includes computational modeling of both the blood flow and the deformation of cells, as well as in-vitro experiments on human erythrocytes. Her research project is part of the Zurich Heart Project, a joint program of the University, ETH and University Hospital Zurich.

Journal Publications

Wiegmann L, de Zélicourt DA, Speer O, Muller A, Goede JS, Seifert B and Kurtcuoglu V (2017) Influence of Standard Laboratory Procedures on Measures of Erythrocyte Damage. Front. Physiol. 8:731. doi: 10.3389/fphys.2017.00731

Wiegmann L, Boës S, de Zélicourt DA, Thamsen B, Schmid Daners M, Meboldt M, Kurtcuoglu V (2017) Blood Pump Design Variations and Their Influence on Hydraulic Performance and Indicators of Hemocompatibility. Annals of Biomedical Engineering. https://doi.org/10.1007/s10439-017-1951-0

Conference Presentations

  1. Wiegmann L, de Zélicourt D, Kurtcuoglu V. Towards a better understanding of hemolysis: Particles’ shear stress histories in a ventricular assist device (VAD), in 42nd Meeting of the European Society of Artificial Organs (ESAO), Leuven, Belgium, 2015
  2. Wiegmann L, de Zélicourt D, Speer O., Kurtcuoglu V. Characterization of blood damage under dynamic and static conditions using multiple hemolysis markers, in 43rd Meeting of the European Society of Artificial Organs (ESAO), Warsaw, Poland, 2016
  3. Boës S, Wiegmann L, Ochsner G, de Zélicourt D, Meboldt M, Kurtcuoglu V, Schmid Daners M. Benchmark of centrifugal impeller designs using computational fluid dynamics: clinical VAD vs. industrial pump, in 43rd Meeting of the European Society of Artificial Organs (ESAO), Warsaw, Poland, 2016
  4. Wiegmann L, Boës S, de Zélicourt D, Thamsen B, Schmid Daners M, Meboldt M, Kurtcuoglu V. Blood pump design variations and their influence on hydraulic performance and hemocompatibility, Gordon Research Seminar & Conference, Stoweflake (VT), USA (2017)
  5. Wiegmann L, Boës S, de Zélicourt D, Thamsen B,  Schmid Daners M, Meboldt M, Kurtcuoglu V. Influence of pump design variations on hydraulic performance and blood damage: a computational fluid dynamics analysis, in 44th Meeting of the European Society of Artificial Organs (ESAO), Vienna, Austria, 2017