People

What children bring to science

Diane de Zélicourt

Junior Group Leader University of Zürich
Institute of Physiology
Winterthurerstr. 190, Y23 J 78
8057 Zürich
+41 (0) 44 635 50 56diane.dezelicourt@physiol.uzh.ch

Short Biography

Diane de Zélicourt graduated with a Master’s of Science in Biomedical Engineering from the Georgia Institute of Technology (Atlanta, GA, USA) in 2004 and an Engineering degree from the Ecole Polytechnique (Palaiseau, France) in 2005. Under the co-supervision of Professors Ajit Yoganathan and Fotis Sotiropoulos, she completed her doctorate at the Georgia Institute of Technology on the topic “Virtual surgical planning of the Fontan procedure” in 2010. Diane currently is the Junior Group leader of Cardiovascular and Systems Physiology within the Interface Group. Her primary research focus is on experimental and computational methods in biomechanics, and their application to understand disease mechanisms and improve device designs/surgical procedures. Specific areas of application include investigations of the cardio-renal coupling in health and disease, and cardiovascular devices or surgeries.

 

Open Position

We currently have an open position in the area of Cardio-renal physiology / systems modeling.

 

 

Selected Publications

ORIGINAL, PEER-REVIEWED PUBLICATIONS

  1. Wiegmann, L., B. Thamsen, D.A. de Zélicourt, M. Granegger, S. Boes, M. Schmid Daners, M. Meboldt and V. Kurtcuoglu. Fluid dynamics in the HeartMate 3: Influence of the artificial pulse feature and residual cardiac pulsation. Artif Organs 43(3), 363 – 376 (2019)
    doi: 10.1111/aor.13346; Publications Collection
  2. Wiegmann, L., S. Boës, D.A. de Zélicourt, B. Thamsen, M. Schmid Daners, M. Meboldt and V. Kurtcuoglu. Blood Pump Design Variations and Their Influence on Hydraulic Performance and Indicators of Hemocompatibility. Ann Biomed Eng 46(3): 417 – 428 (2018)
    doi: 10.1007/s10439-017-1951-0; Publications Collection.
  3. Siallagan, D., Y. Loke, L. Olivieri, J. Opfermann, C. S. Ong, D.A. de Zélicourt, A. Petrou, M. Schmid Daners, V. Kurtcuoglu, M. Meboldt, K. Nelson, L. Vricella, J. Johnson, N. Hibino, A. Krieger Virtual surgical planning, flow simulation and 3D electro-spinning of patient-specific grafts to optimize Fontan hemodynamics. J Thorac Cardiovasc Surg 155(4): 1734-1742 (2018)
    doi: 10.1016/j.jtcvs.2017.11.068; Publications Collection.
  4. Wiegmann, L., D.A. de Zélicourt, O. Speer, A. Muller, J. S. Goede, B. Seifert and V. Kurtcuoglu. Influence of standard laboratory procedures on measures of erythrocyte damage. Frontiers Physiol 8: 731 (2017)
    doi: 10.3389/fphys.2017.00731; Publications Collection.
  5. Asgari, M., D.A. de Zélicourt and V. Kurtcuoglu. Barrier dysfunction or drainage reduction: differentiating causes of CSF protein increase. Fluids Barriers CNS 14(1): 14 (2017)
    doi: 10.1186/s12987-017-0063-4; Publications Collection.
  6. Thiel, C.S., D.A. de Zélicourt, S. Tauber, A. Adrian, M. Franz, D.M. Simmet, K. Schoppmann, S. Hauschild, S. Krammer, M. Christen, G. Bradacs, K. Paulsen, S.A. Wolf, M. Braun, J. Hatton, V. Kurtcuoglu, S. Franke, S. Tanner, S. Cristoforetti, B. Sick, B. Hock and O. Ullrich. Rapid adaptation to microgravity in mammalian macrophage cells. Sci Rep 7(1): 43 (2017)
    doi: 10.1038/s41598-017-00119-6; Publications Collection.
  7. Asgari, M., D.A. de Zélicourt and V. Kurtcuoglu. Glymphatic solute transport does not require bulk flow. Sci Rep 6: 38635 (2016)
    doi: 10.1038/srep38635; Publications Collection.
  8. Asgari, M., D.A. de Zélicourt and V. Kurtcuoglu. How astrocyte networks may contribute to cerebral metabolite clearance. Sci Rep 5: 15024 (2015)
    doi: 10.1038/srep15024; Publications Collection.
  9. Haggerty, C.M., M. Restrepo, E. Tang, D.A. de Zélicourt, K.S. Sundareswaran, L. Mirabella, J. Bethel, K.K. Whitehead, M.A. Fogel and A.P. Yoganathan. Fontan hemodynamics from 100 patient-specific cardiac magnetic resonance studies: a computational fluid dynamics analysis. J Thorac Cardiovasc Surg 148(4): 1481-1489 (2014)
    doi: 10.1016/j.jtcvs.2013.11.060
  10. Siyahhan, B., V. Knobloch, D.A. de Zélicourt, M. Asgari, M. Schmid Daners, D. Poulikakos and V. Kurtcuoglu. Flow induced by ependymal cilia dominates near-wall cerebrospinal fluid dynamics in the lateral ventricles. J R Soc Interface 11(94): 20131189 (2014)
    doi: 10.1098/rsif.2013.1189; Publications Collection.
  11. Bottan, S., M. Schmid Daners, D.A. de Zélicourt, N. Fellner, D. Poulikakos and V. Kurtcuoglu. Assessment of intracranial dynamics in hydrocephalus: effects of viscoelasticity on the outcome of infusion tests. J Neurosurg 119(6): 1511-1519 (2013)
    doi: 10.3171/2013.8.JNS122497; Publications Collection.
  12. Haggerty, C.M., K.R. Kanter, M. Restrepo, D.A. de Zélicourt, W.J. Parks, J. Rossignac, M.A. Fogel and A.P. Yoganathan. Simulating hemodynamics of the Fontan Y-graft based on patient-specific in vivo connections. J Thorac Cardiovasc Surg 145(3): 663-670 (2013)
  13. Tang, E., C.M. Haggerty, R.H. Khiabani, D.A. de Zélicourt, J. Kanter, F. Sotiropoulos, M.A. Fogel and A.P. Yoganathan. Numerical and experimental investigation of pulsatile hemodynamics in the total cavopulmonary connection. J Biomech 46(2): 373-382 (2013)
    doi: 10.1016/j.jbiomech.2012.11.003;

 

REVIEWS, BOOK CHAPTERS

  1. de Zélicourt, D.A. and V. Kurtcuoglu. Patient-Specific Surgical Planning, Where Do We Stand? The Example of the Fontan Procedure. Ann Biomed Eng 44(1): 174-186 (2016)
    doi: 10.1007/s10439-015-1381-9; Publications Collection.
  2. Haggerty, C.M., L. Mirabella, M. Restrepo, D.A. de Zélicourt, J. Rossignac, F. Sotiropoulos, T.L. Spray, K.R. Kanter, M.A. Fogel, and A.P. Yoganathan, Patient-Specific Surgery Planning for the Fontan Procedure, in Computer Models in Biomechanics. Springer. p. 217-228. (2013)
    doi: 10.1007/978-94-007-5464-5_16;
  3. de Zélicourt, D.A.,N. Steele, and A.P. Yoganathan, Advances in Computational Simulations for Interventional Treatments and Surgical Planning, in Image-Based Computational Modeling of the Human Circulatory and Pulmonary Systems. Springer. p. 343-373. (2011)
    doi: 10.1007/978-1-4419-7350-4_9;
  4. de Zélicourt, D.A., A. Marsden, M.A. Fogel and A.P. Yoganathan. Imaging and patient-specific simulations for the Fontan surgery: current methodologies and clinical applications. Prog Pediatr Cardiol 30(1-2): 31-44 (2010)
    doi: 10.1016/j.ppedcard.2010.09.005;

 

OTHER PUBLICATIONS

Monographs

  1. de Zélicourt, D.A., Pulsatile Fontan hemodynamics and patient-specific surgical planning: A numerical investigation, PhD Dissertation in Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA. (2010)
    GeorgiaTech Thesis and Dissertations
  2. de Zélicourt, D.A., A Mechanical Fluid Assessment of Anatomical Models of the Total Cavopulmonary Connection (TCPC), Master’s thesis in Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA. (2004)
    GeorgiaTech Thesis and Dissertations

 

Conference Proceedings

  1. Boraschi, A., Granegger, M., Thamsen, B., Bozzi, S., Schmid Daners, M., Redaelli, A., Kurtcuoglu, V., Consolo, F., de Zélicourt, D.A. Impact of speed modulation sequences on hemodynamics in VADs: comparison of the Heartmate 3 artificial pulse and HVAD lavare cycle. The International Journal of Artificial Organs 42(8): 386-474, European Society of Artificial Organs (ESAO) conference, Hannover, Germany, September (2019)
    doi: 10.1177/0391398819860985;
  2. Boraschi, A., Granegger, M., Thamsen, B., Bozzi, S., Schmid Daners, M., Redaelli, A., Kurtcuoglu, V., de Zélicourt, D.A. and Consolo, F. Comparative analysis of the thrombogenic potential of the Heartmate 3 and HeartWare HVAD cardiac pumps: a “numerical rationale” of clinical outcomes. The International Journal of Artificial Organs 42(8): 386-474, European Society of Artificial Organs (ESAO) conference, Hannover, Germany, September (2019)
    doi: 10.1177/0391398819860985;
  3. Wiegman, L. Thamsen, B., de Zélicourt, D.A., Granegger, M. Boës, S., Schmid Daners, M., Meboldt, M., and V. Kurtcuoglu. Heartmate 3 hemodynamics under dynamic operating conditions: Effect of cardiac pulsatility and artificial pulse feature. The International Journal of Artificial Organs 41(9): 486-631, European Society of Artificial Organs (ESAO) conference, Madrid, Spain, September 12-15 (2018)
    doi: 10.1177/0391398818785526;
  4. Wiegman, L., Boës, S., de Zélicourt, D.A., Thamsen, B., Schmid Daners, M., Meboldt, M., and V. Kurtcuoglu. Influence of pump design variations on hydraulic performance and blood damage: a computational fluid dynamics analysis. The International Journal of Artificial Organs, 40(8): 382-428. European Society of Artificial Organs (ESAO) conference, Vienna, Austria, September 5-7 (2017)
    doi: 10.5301/ijao.5000629;
  5. Wiegmann, L., de Zélicourt, D.A., Speer, O., Muller, A., Goede, J.S., Seifert, B., and V. Kurtcuoglu. Characterization of blood damage under dynamic and static conditions using multiple hemolysis markers. The International Journal of Artificial Organs, 40(8): 430-475. European Society of Artificial Organs (ESAO) conference, Vienna, Austria, September 5-7 (2017)
    doi: 10.5301/ijao.5000641;
  6. Boës, S., Wiegmann, L., Ochsner, G., de Zélicourt, D.A., Meboldt, M., Kurtcuoglu, V., and M. Schmid Daners. Blood damage by handling: the crux of the matter. The International Journal of Artificial Organs, 39(7): 321-357. European Society of Artificial Organs (ESAO) conference, Warsaw, Poland, September 14-17 (2016)
    doi: 10.5301/ijao.5000507;
  7. Wiegmann, L., de Zélicourt, D.A., Speer, O., and V. Kurtcuoglu. Characterization of blood damage under dynamic and static conditions using multiple hemolysis markers. The International Journal of Artificial Organs, 39(7): 321-357. European Society of Artificial Organs (ESAO) conference, Warsaw, Poland, September 14-17 (2016)
    doi: 10.5301/ijao.5000507;
  8. de Zélicourt, D.A., and V. Kurtcuoglu. A multiscale poroelastic framework for large deformations of the brain. In P. Nithiarasu, & E. Budyn (Eds.), 4th International Conference Computational & Mathematical Biomedical Engineering, 29 June – 1 July, Paris, France. CMBE online proceedings series; Vol. 2015: 436-439. (2015)
    CMBE Proceedings;